Dementia with Lewy bodies (DLB) is a common disorder with low clinical sensitivity. We analyzed data from the National Alzheimer’s Coordinating Center database (NACC is funded by NIA/NIH Grant U01 AG016976) collected by 39 past/present Alzheimer’s Disease Research Centers between September 2005 and May 2020. Enrollment prior to dementia diagnosis, a subsequent diagnosis of DLB, and postmortem neuropathological data were required for inclusion. The sample (n=32) was 84.4% male and 96.9% Caucasian. There was no significant difference in LB-pathology (n=25) and non-LB-pathology (n=7) groups in age at enrollment (p=0.10) or death (p-0.20). In the non-LB-pathology group, five (71.4%) had Alzheimer’s (AD) pathology, one (14.2%) had progressive supranuclear palsy (PSP) and one (14.2%) had tangle only tauopathy. One participant with AD-pathology also had ubiquitin-positive inclusions, indicative of frontotemporal dementia. All seven non-LB-pathology participants demonstrated parkinsonism; however, none had REM sleep behavior disorder (RBD) or cognitive fluctuations. Only six non-LB-pathology participants had neuropsychological data. Participants with AD pathology demonstrated impairment in verbal fluency and confrontation naming, but their memory profiles were not amnestic. The participant with PSP demonstrated severe executive dysfunction and cognitive slowing. The participant with tangle-predominant dementia demonstrated severe impairment in learning/memory. Parkinsonism is common in individuals misdiagnosed with DLB.
|First Author||Kathryn A Wyman-Chick|
|Second Author||Laura C Cunningham|
|Third Author||Lauren R O'Keefe|
|Fourth Author||Matthew J Barrett|