The offspring of patients with Huntington’s Disease (HD) have a 50% chance of inheriting the fully-penetrant, mutant gene that causes HD. Cognitive symptoms of HD may emerge earlier than motor symptoms and are an important marker of disease onset. We conducted a latent profile analysis to investigate profiles of neurocognitive functioning in this population. 86 offspring of patients with HD (M age= 21.02±7.81 years; 54.65% female; 93% White) completed the NIH Toolbox Cognition Battery as part of an ongoing study in which investigators are blind to offspring genetic status. Models were fit using the mixture package in R. Predictors were fully-adjusted T-scores for five subtests of the Toolbox that assessed shifting (DCCS), inhibitory control/attention (FICA), working memory (LSWM), episodic memory (PSM), and processing speed (PCPS). Two profiles emerged from our model. In one profile (n=67), scores were within one standard deviation of the normative mean: M_DCCS=52.05; M_FICA= 42.26; M_LSWM=49.86; M_PSM=48.65; M_PCPS=52.31. In the second profile (n=19), scores were between one and more than two standard deviations below the normative mean: M_DCCS=35.62; M_FICA= 28.13; M_LSWM=32.15; M_PSM=29.59; M_PCPS=37.97. Next steps for this research are to determine overlap between these profiles and genetic status and examine associations with relevant demographic and medical characteristics.
|First Author||Marissa C Roth|
|Second Author||Abagail E Ciriegio|
|Third Author||Cara Guthrie|
|Fourth Author||Kelly H Watson|
|Fifth Author||Anna C Pfalzer|
|Sixth Author||Daniel O Claassen|
|Seventh Author||Bruce E Compas|