Poster Abstracts

Abstract

Patients undergoing autologous hematopoietic stem cell transplant (HCT) are at risk for cognitive changes and death, yet this population remains understudied. We examined cognitive changes following autologous HCT in relation to mortality. Participants (N = 52; 11 patients deceased) underwent cognitive assessments prior to HCT, 30 days post-HCT, and 100 days post-HCT. Participants completed tasks of processing speed, working memory, executive-mediated learning, and visual recall using the computerized CogState battery. The median length of time from transplant to death was 5.32 years. Survival analyses indicated that slower processing speed (HR = 3.00) and errors on an executive-mediated visual learning task (HR = 2.78) prior to HCT were associated with increased risk of death after HCT. Declines in processing speed (HR = .30) and visual learning (HR = .95) between pre-HCT and day 30 post-HCT were associated with a decreased risk for death. However, these findings likely reflect lower baseline scores among deceased patients. Decline in visual recall was associated with an increased risk of death (HR = 1.03). Findings suggest that pre-HCT cognition may have utility as a predictor of mortality. Cognitive fluctuations in the months following HCT are common and should be considered within the context of baseline performance.

First AuthorEllen Elizabeth Haynes Johnson
Second AuthorSung Won Choi
Third AuthorJohn Stratton
Fourth AuthorAllison Sylvia
Fifth AuthorKristen L. Votruba